Reaction: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
- in pathway: Amino acid transport across the plasma membrane
SLC7A9 as a heterodimer with SLC3A1 in the plasma membrane mediates the exchange of arginine (L-Arg), lysine (L-Lys), or cystine (CySS-) for leucine (L-Leu) and other neutral amino acids. The physiological concentrations of these amino acids favor neutral amino acid export and arginine/lysine/cystine import. Defects in SLC7A9 and SLC3A1 cause cystinuria. In the body, this transport process is prominent in the kidney (Mizoguchi et al. 2001).
Reaction - small molecule participants:
L-Leu [extracellular region]
L-Leu [cytosol]
Reactome.org reaction link: R-HSA-379432
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Reaction input - small molecules:
L-leucine zwitterion
Reaction output - small molecules:
L-leucine zwitterion
Reactome.org link: R-HSA-379432