Reaction: COMT transfers Met to DOPAC to form HVA
- in pathway: Enzymatic degradation of Dopamine by monoamine oxidase
3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).
Reaction - small molecule participants:
HVA [cytosol]
HCYS [cytosol]
DOPAC [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-379464
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Reaction input - small molecules:
(3,4-dihydroxyphenyl)acetate
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
homovanillic acid
homocysteine zwitterion
Reactome.org link: R-HSA-379464