Reaction: histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
HARS (cytosolic histidyl tRNA synthetase) catalyzes the reaction of histidine, tRNA(His), and ATP to form His-tRNA(His), AMP, and pyrophosphate (Lee et al. 2002).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-His [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-379844
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Reaction input - small molecules:
L-histidinium(1+)
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379844