Reaction: phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
FARS (cytosolic phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a heterotetramer of two alpha and two beta subunits (Moor et al. 2002).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-Phe [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-379848
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Reaction input - small molecules:
L-phenylalanine zwitterion
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379848