Reaction: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
Multifunctional EPRS (cytosolic glutamyl prolyl tRNA synthetase) catalyzes the reaction of glutamate, tRNA(Glu), and ATP to form Glu tRNA(Glu), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Pro) with proline. The enzyme is found in the cell as a component of the mutienzyme aminoacyl tRNA synthetase complex (Kaiser et al. 1994).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-Glu [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-379861
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Reaction input - small molecules:
L-glutamate(1-)
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379861