Reaction: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
Multifunctional EPRS (cytosolic glutamyl-prolyl tRNA synthetase) catalyzes the reaction of proline, tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Glu) with glutamate. The enzyme is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaiser et al. 1994).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Pro [cytosol]
Reactome.org reaction link: R-HSA-379865
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Reaction input - small molecules:
ATP(4-)
L-proline zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379865