Reaction: cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
CARS (cytosolic cysteinyl tRNA synthetase) catalyzes the reaction of cysteine, tRNA(cys), and ATP to form Cys-tRNA(Cys), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homomultimer, probably a dimer (Davidson et al. 2001).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-Cys [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-379887
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Reaction input - small molecules:
L-cysteine zwitterion
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379887