Reaction: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
LARS (cytosolic leucyl tRNA synthetase) catalyzes the reaction of leucine, tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Ling et al. 2005).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Leu [cytosol]
Reactome.org reaction link: R-HSA-379974
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Reaction input - small molecules:
ATP(4-)
L-leucine zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379974