Reaction: tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
WARS (cytosolic tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bange et al. 1992; Rubin et al. 1991; Yu et al. 2004).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-Trp [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-379977
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Reaction input - small molecules:
L-tryptophan zwitterion
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379977