Reaction: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
QARS (cytosolic glutaminyl tRNA synthetase) catalyzes the reaction of glutamine, tRNA(Gln), and ATP to form Gln-tRNA(Gln), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both the cytosolic and mitochondrial QARS enzymes (Lamour et al. 1994).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-379982
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Reaction input - small molecules:
ATP(4-)
L-glutamine zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379982