Reaction: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
MARS (cytosolic methionyl tRNA synthetase) catalyzes the reaction of methionine, tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaminska et al. 2001).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Met [cytosol]
Reactome.org reaction link: R-HSA-379994
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Reaction input - small molecules:
ATP(4-)
L-methionine zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-379994