Reaction: threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
TARS (cytosolic threonyl tRNA synthetase) catalyzes the reaction of threonine, tRNA(Thr), and ATP to form Thr-tRNA(Thr), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer (Pan et al. 1982).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Thr [cytosol]
Reactome.org reaction link: R-HSA-380002
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Reaction input - small molecules:
ATP(4-)
L-threonine zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-380002