Reaction: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
KARS (cytosolic lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
L-Lys [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-380008
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Reaction input - small molecules:
L-lysinium(1+)
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-380008