Reaction: valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
- in pathway: Cytosolic tRNA aminoacylation
VARS (cytosolic valyl tRNA synthetase) catalyzes the reaction of valine, tRNA(Val), and ATP to form Val-tRNA(Val), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Vilalta et al. 1993).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
L-Val [cytosol]
Reactome.org reaction link: R-HSA-380042
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Reaction input - small molecules:
ATP(4-)
L-valine zwitterion
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-380042