Reaction: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
- in pathway: Mitochondrial tRNA aminoacylation
MARS2 (mitochondrial methionyl tRNA synthetase) catalyzes the reaction of methionine, mitochondrial tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Spencer et al. 2004).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
L-Met [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-380157
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Reaction input - small molecules:
L-methionine zwitterion
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-380157