Reaction: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
- in pathway: Mitochondrial tRNA aminoacylation
LARS2 (mitochondrial leucyl tRNA synthetase) catalyzes the reaction of leucine, mitochondrial tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Bullard et al. 2000).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
L-Leu [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-380200
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Reaction input - small molecules:
L-leucine zwitterion
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-380200