Reaction: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
- in pathway: Mitochondrial tRNA aminoacylation
KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
ATP [mitochondrial matrix]
L-Lys [mitochondrial matrix]
Reactome.org reaction link: R-HSA-380233
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Reaction input - small molecules:
ATP(4-)
L-lysinium(1+)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-380233