Reaction: histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
- in pathway: Mitochondrial tRNA aminoacylation
HARS2 (mitochondrial histidyl tRNA synthetase) catalyzes the reaction of histidine, mitochondrial tRNA(His), and ATP to form His-tRNA(His), AMP, and pyrophosphate. The enzyme is a class II tRNA synthetase (O'Hanlon et al. 1995).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
L-His [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-380234
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Reaction input - small molecules:
L-histidinium(1+)
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-380234