Reaction: Reuptake of serotonin from the synapse
- in pathway: Na+/Cl- dependent neurotransmitter transporters
The human gene SLC6A4 encodes the sodium-dependent serotonin transporter 5HTT which mediates the re-uptake of serotonin from the synaptic cleft thus terminating the action of serotonin (Canli T and Lesch KP, 2007). The serotonin taken up in the cytosol from the synaptic cleft may be recycled into synaptic vesicles or metabolized.
Reaction - small molecule participants:
5HT [cytosol]
Na+ [cytosol]
5HT [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-380620
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Reaction input - small molecules:
serotonin(1+)
sodium(1+)
Reaction output - small molecules:
serotonin(1+)
sodium(1+)
Reactome.org link: R-HSA-380620