Reaction: Phosphorylated AMPK binds AMP
- in pathway: Energy dependent regulation of mTOR by LKB1-AMPK
If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the AMPK-gamma subunit, which inhibits the dephosphorylation of the AMPK-alpha subunit resulting in activation of AMPK. It is not clear, as of yet, whether AMP binds to unphosphorylated AMPK.
Reaction - small molecule participants:
AMP [cytosol]
Reactome.org reaction link: R-HSA-380930
======
Reaction input - small molecules:
adenosine 5'-monophosphate(2-)
Reaction output - small molecules:
Reactome.org link: R-HSA-380930