Reaction: Phosphorylated IRE1 dimer binds ADP
- in pathway: IRE1alpha activates chaperones
Phosphorylation of the C-terminal region causes a loop in the C-terminus to change position, enabling access to an ADP-binding pocket. Phosphorylated IRE1-alpha dimers bind ADP in preference to ATP.
Reaction - small molecule participants:
ADP [cytosol]
Reactome.org reaction link: R-HSA-381116
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Reaction input - small molecules:
ADP(3-)
Reaction output - small molecules:
Reactome.org link: R-HSA-381116