Reaction: HCO3- transport through ion channel
- in pathway: ABC-family proteins mediated transport
Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). CFTR regulates both HCO(3)(-) secretion and HCO(3)(-) salvage in secretory epithelia.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
HCO3- [extracellular region]
H2O [cytosol]
HCO3- [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-383190
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Reaction input - small molecules:
water
hydrogencarbonate
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
hydrogencarbonate
Reactome.org link: R-HSA-383190