Reaction: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
- in pathway: Senescence-Associated Secretory Phenotype (SASP)
Phosphorylation of CEBPB (C/EBP-beta) transcription factor on threonine residue T235 happens downstream of activated RAS, is mediated by MAPKs - likely MAPK3 (ERK1) and MAPK1 (ERK2), and positively affects CEBPB-mediated transcription of IL6 (Nakajima et al. 1993).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-3857329
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-3857329