Reaction: ALDH3A2-2 oxidizes pristanal to pristanate
- in pathway: Alpha-oxidation of phytanate
Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).
Reaction - small molecule participants:
H+ [peroxisomal matrix]
pristanate [peroxisomal matrix]
NADH [peroxisomal matrix]
Pristanal [peroxisomal matrix]
NAD+ [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389609
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Reaction input - small molecules:
pristanal
NAD(1-)
Reaction output - small molecules:
hydron
pristanate
NADH(2-)
Reactome.org link: R-HSA-389609