Reaction: 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
- in pathway: Alpha-oxidation of phytanate
Peroxisomal HACL1 catalyzes the reaction of 2-hydroxyphytanoyl-CoA to form pristanal and formyl-CoA. The active form of the enzyme is a homotetramer, with one Mg++ and one molecule of thiamin pyrophosphate bound to each monomer (Croes et al. 1997; Foulon et al. 1999).
Reaction - small molecule participants:
FOR-CoA [peroxisomal matrix]
Pristanal [peroxisomal matrix]
3S2HPhy-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389611
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Reaction input - small molecules:
2-hydroxyphytanoyl-CoA
Reaction output - small molecules:
formyl-CoA
pristanal
Reactome.org link: R-HSA-389611