Reaction: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
- in pathway: PD-1 signaling
PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.
Reaction - small molecule participants:
PPi [cytosol]
Reactome.org reaction link: R-HSA-389758
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Reaction input - small molecules:
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-389758