Reaction: glycine + O2 => glyoxylate + H2O2 + NH4+
- in pathway: Glyoxylate metabolism and glycine degradation
Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).
Reaction - small molecule participants:
glyoxylate [peroxisomal matrix]
NH4+ [peroxisomal matrix]
H2O2 [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
Gly [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389821
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Reaction input - small molecules:
dioxygen
water
glycine zwitterion
Reaction output - small molecules:
glyoxylic acid
ammonium
hydrogen peroxide
Reactome.org link: R-HSA-389821