Reaction: glyoxylate + NADPH + H+ => glycolate + NADP+
- in pathway: Glyoxylate metabolism and glycine degradation
Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).
Reaction - small molecule participants:
glycolate [peroxisomal matrix]
NADP+ [peroxisomal matrix]
H+ [peroxisomal matrix]
glyoxylate [peroxisomal matrix]
NADPH [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389826
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Reaction input - small molecules:
hydron
glyoxylic acid
NADPH
Reaction output - small molecules:
glycolate
NADP(+)
Reactome.org link: R-HSA-389826