Reaction: HAO1 tetramer oxidizes glycolate to glyoxylate
- in pathway: Glyoxylate metabolism and glycine degradation
Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glycolate and O2 to form glyoxylate and H2O2. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).
Reaction - small molecule participants:
glyoxylate [peroxisomal matrix]
H2O2 [peroxisomal matrix]
O2 [peroxisomal matrix]
glycolate [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389842
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Reaction input - small molecules:
dioxygen
glycolate
Reaction output - small molecules:
glyoxylic acid
hydrogen peroxide
Reactome.org link: R-HSA-389842