Reaction: ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA
- in pathway: Beta-oxidation of pristanoyl-CoA
In human liver and kidney tissue, monomeric peroxisomal ACOX2 (bound to FAD cofactor) catalyzes the reaction of (2S)-pristanoyl-CoA and O2 to form trans-2,3-dehydropristanoyl-CoA and H2O2 (Vanhove et al. 1993; Baumgart et al. 1996). A putative acyl-coenzyme A oxidase-like protein ACOXL could catalyse this type of reaction but its activity has not yet been determined.
Reaction - small molecule participants:
H2O2 [peroxisomal matrix]
trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
O2 [peroxisomal matrix]
(2S) Pristanoyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389889
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Reaction input - small molecules:
dioxygen
(2S)-pristanoyl-CoA
Reaction output - small molecules:
hydrogen peroxide
(E)-2,3-didehydropristanoyl-CoA
Reactome.org link: R-HSA-389889