Reaction: (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
- in pathway: Beta-oxidation of pristanoyl-CoA
Peroxisomal ACOX3 catalyzes the reaction of (2S)-pristanoyl-CoA and O2 to form trans-2,3-dehydropristanoyl-CoA and H2O2. ACOX3 protein and enzyme activity have been observed in prostate tumors, but are undetectable in normal prostate tissue as well as in liver and kidney (where ACOX2 catalyzes the oxidation of pristanoyl-CoA) (Zha et al. 2005; Vanhooren et al. 1997). The physiological consequences of this differential gene expression are unknown.
Reaction - small molecule participants:
H2O2 [peroxisomal matrix]
trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
O2 [peroxisomal matrix]
(2S) Pristanoyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389891
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Reaction input - small molecules:
dioxygen
(2S)-pristanoyl-CoA
Reaction output - small molecules:
hydrogen peroxide
(E)-2,3-didehydropristanoyl-CoA
Reactome.org link: R-HSA-389891