Reaction: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
- in pathway: Beta-oxidation of pristanoyl-CoA
Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,3-dehydropristanoyl-CoA and H2O to form 3-hydroxypristanoyl-CoA. The enzyme is bifunctional - an aminoterminal domain catalyzes the dehydrogenation of a variety of 3-hydroxyacyl-CoA's and a carboxyterminal domain catalyzes the hydration of a variety of trans-2,3-dehydroacyl-CoA's, the reaction annotated here (Jiang et al. 1996, 1997). Defects in the enzyme are associated with a severe disorder of peroxisomal fatty acid metabolism in humans (Ferdinandusse et al. 2006).
Reaction - small molecule participants:
3-hydroxypristanoyl-CoA [peroxisomal matrix]
H2O [peroxisomal matrix]
trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389986
======
Reaction input - small molecules:
water
(E)-2,3-didehydropristanoyl-CoA
Reaction output - small molecules:
3-hydroxypristanoyl-CoA
Reactome.org link: R-HSA-389986