Reaction: Hydrolysis of ATP and release of folded actin from CCT/TriC
- in pathway: Folding of actin by CCT/TriC
TriC/CCT-mediated beta-actin folding involves rapid ATP-independent formation of a binary complex, followed by a slower ATP-dependent release of the native product (Gao et al., 1992). Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003).
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-390453
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-390453