Reaction: 5-HT4, 6 and 7 receptors can bind serotonin
- in pathway: Serotonin receptors
The 5-HT4 receptor (Van den Wyngaert I et al, 1997) is located in the alimentary tract, bladder, heart and adrenal gland as well as the central nervous system (CNS). It modulates the release of various neurotransmitters. Multiple transcripts encode proteins with distinct C-terminal sequences, but the full-length nature of some transcript variants has not been determined (Blondel O et al, 1998). The 5-HT6 receptor (Kohen R et al, 1996) is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. The 5-HT7 receptor (Stam NJ et al, 1997) plays a role in vasculature smooth muscle relaxation and in the GI tract. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep.
All these receptor types mediate their actions by coupling to the G protein alpha-s subtype, which increases cellular cAMP levels (Baker LP et al, 1998; Zhang JY et al, 2003).
All these receptor types mediate their actions by coupling to the G protein alpha-s subtype, which increases cellular cAMP levels (Baker LP et al, 1998; Zhang JY et al, 2003).
Reaction - small molecule participants:
5HT [extracellular region]
Reactome.org reaction link: R-HSA-390931
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Reaction input - small molecules:
serotonin(1+)
Reaction output - small molecules:
Reactome.org link: R-HSA-390931