Reaction: DP2 receptor can bind PGD2
- in pathway: Prostanoid ligand receptors
G protein-coupled receptor 44 (GPR44) is a GPCR that has recently been found to belong to the prostanoid receptor family and named DP2 (CRTH2) (Marchese A et al, 1999). The effects of PGD2 bound to the receptor are mediated by coupling with the G protein alpha i/o subunit which inhibits cAMP production (Sawyer N et al, 2002).
Reaction - small molecule participants:
PGD2 [extracellular region]
Reactome.org reaction link: R-HSA-391934
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Reaction input - small molecules:
prostaglandin D2
Reaction output - small molecules:
Reactome.org link: R-HSA-391934