Reaction: IP receptor can bind prostacyclin
- in pathway: Prostanoid ligand receptors
Prostacyclin (PGI2) prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation) and is an effective vasodilator. Binding to its receptor (IP, PTGIR) (Boie et al. 1994) allows coupling to and activation of the G protein alpha s subunit, which leads to activation of cAMP and increase in protein kinase A (PKA) activity (Schwaner et al. 1995).
Reaction - small molecule participants:
PGI2 [extracellular region]
PGI2 [extracellular region]
Reactome.org reaction link: R-HSA-391942
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Reaction input - small molecules:
prostaglandin I2
prostaglandin I2
Reaction output - small molecules:
Reactome.org link: R-HSA-391942