Reaction: NO binds to Guanylate Cyclase
- in pathway: Nitric oxide stimulates guanylate cyclase
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.
Reaction - small molecule participants:
NO [cytosol]
NO [cytosol]
Reactome.org reaction link: R-HSA-392143
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Reaction input - small molecules:
nitric oxide
nitric oxide
Reaction output - small molecules:
Reactome.org link: R-HSA-392143