Reaction: Dissociation of the P2Y purinoceptor 12:Gi complex
- in pathway: ADP signalling through P2Y purinoceptor 12
The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Reaction - small molecule participants:
ADP [extracellular region]
Reactome.org reaction link: R-HSA-392202
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Reaction input - small molecules:
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-392202