Reaction: Activation of EPACs by cAMP
- in pathway: Rap1 signalling
EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function.
Reaction - small molecule participants:
cAMP [cytosol]
Reactome.org reaction link: R-HSA-392834
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Reaction input - small molecules:
3',5'-cyclic AMP(1-)
Reaction output - small molecules:
Reactome.org link: R-HSA-392834