Reaction: SFKs phosphorylate VAV2,3
- in pathway: EPH-ephrin mediated repulsion of cells
Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (VAV) is transiently tyrosine phosphorylated and activated in neurons, possibly by Src family kinases (SFKs). VAV2 and VAV3 are phosphorylated on Y172 and Y173 respectively in the acidic domain and this phosphorylation disrupts the inhibitory interaction of the acidic domain with the DH domain (Cowan et al. 2005, Marignani & Carpenter 2001).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-3928604
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-3928604