Reaction: PAK1 autophosphorylates
- in pathway: EPHB-mediated forward signaling
Autophosphorylation of serine/threonine-protein kinase PAK1 (PAK1) is required for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate catalytic activity. As a result, active PAK1 phosphorylates substrates like LIMK (LIM domain kinase) that are involved in remodelling of the actin cytoskeleton.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-3928620
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-3928620