Reaction: Diacylgycerol activates Protein kinase C, alpha type
- in pathway: EGFR Transactivation by Gastrin
Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysis in G alpha (q) signalling, remains in the plasma membrane and binds Protein Kinase C alpha (PKC-alpha), causing PKC-alpha to translocate from the cytosol to the plasma membrane. PKC-alpha is thereby activated and phosphorylates target proteins.
Reaction - small molecule participants:
DAG [plasma membrane]
DAG [plasma membrane]
Reactome.org reaction link: R-HSA-400015
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Reaction input - small molecules:
1,2-diacyl-sn-glycerol
1,2-diacyl-sn-glycerol
Reaction output - small molecules:
Reactome.org link: R-HSA-400015