Reaction: NANS converts ManNAc-6-P to Neu5Ac-9-P
- in pathway: Sialic acid metabolism
Sialic acid synthase (NANS, SAS) can convert N-acetylmannosamine 6-phosphate (ManNAc-6-P) to N-acetylneuraminate 9-phosphate (Neu5Ac-9-P) (Lawrence et al. 2000). NANS shows lower activity towards ManNAc and can convert it to Neu5Ac (not shown here, Lawrence et al. 2000).
Reaction - small molecule participants:
Pi [cytosol]
Neu5Ac-9-P [cytosol]
H2O [cytosol]
ManNAc-6-P [cytosol]
PEP [cytosol]
Reactome.org reaction link: R-HSA-4084976
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Reaction input - small molecules:
water
aldehydo-N-acetyl-D-mannosamine 6-phosphate
phosphonatoenolpyruvate
Reaction output - small molecules:
hydrogenphosphate
N-acetylneuraminic acid 9-phosphate
Reactome.org link: R-HSA-4084976