Reaction: ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
- in pathway: Sialic acid metabolism
The alpha-2,6-sialyltransferases 1-6 (ST6GALNAC1-6) are able to transfer a sialic acid (Neu5Ac) moiety to the terminal N-acetylgalactosaminyl (GalNAc-R) residue of O-glycosylated proteins, glycoproteins and some gangliosides. Neu5Ac is added to GalNAc-R via an alpha-2,6 linkage (Ikehara et al. 1999, Samyn-Petit et al, 2000, Harduin-Lepers et al. 2000, Tsuchida et al. 2003, Senda et al. 2007). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, GalNAc-R is shown in a generic form where R represents other sugars O-linked to proteins which can result in a large variability in glycoconjugate structures.
Reaction - small molecule participants:
Neu5Ac-2,6-GalNAc-R [Golgi lumen]
CMP [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
GalNAc-R [Golgi lumen]
Reactome.org reaction link: R-HSA-4084980
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
N-acetyl-D-galactosaminyl group
Reaction output - small molecules:
alpha-N-acetylneuraminyl-(2->6)-N-acetyl-alpha-D-galactosaminyl group
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-4084980