Reaction: CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac
- in pathway: Sialic acid metabolism
Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase1 (CMAS) transfers cytidine 5-monophosphate from a CTP donor to N-acetylneuraminate (Neu5Ac) to form CMP-Neu5Ac. CMAS is ubiquitously expressed and localizes to the nucleus in mammalian cells. The active form of the enzyme is a homotetramer (a dimer of dimers) (Lawrence et al. 2001, Huizing 2005). CMP-Neu5Ac is the donor substrate for sialyltransferases.
Reaction - small molecule participants:
PPi [nucleoplasm]
CMP-Neu5Ac [nucleoplasm]
CTP [nucleoplasm]
Neu5Ac [nucleoplasm]
Reactome.org reaction link: R-HSA-4084982
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Reaction input - small molecules:
CTP(4-)
N-acetylneuraminate
Reaction output - small molecules:
diphosphate(3-)
CMP-N-acetyl-beta-neuraminate(2-)
Reactome.org link: R-HSA-4084982