Reaction: NEU2 hydrolyzes Neu5Ac from glycoconjugates
- in pathway: Sialic acid metabolism
Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU2 (cytosolic sialidase) hydrolyzes Neu5Ac from glycoconjugates with alpha2,3-, alpha2,6- or alpha2,8-linked terminal sialated residues in the cytosol (Monti et al. 1999, Chavas et al. 2005).
Reaction - small molecule participants:
Neu5Ac [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-4085029
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Reaction input - small molecules:
water
Reaction output - small molecules:
N-acetylneuraminate
Reactome.org link: R-HSA-4085029