Reaction: ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)
- in pathway: Sialic acid metabolism
The beta-galactoside alpha-2,6-sialyltransferases 1 and 2 (ST6GAL1,2) are able to transfer a sialic acid (Neu5Ac) moiety to the terminal galactosyl (Gal-R) residue of O-glycosylated proteins and some gangliosides. Neu5Ac is added to Gal-R via an alpha-2,6 linkage (Wu et al. 2011, Takashima et al. 2002, Krzewinski-Recchi et al. 2003). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, Gal is shown in a generic form where R represents other sugars O-linked to proteins. Highest activity is observed toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups.
Reaction - small molecule participants:
CMP [Golgi lumen]
Neu5Ac-2,6-Gal-R [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Gal-R [Golgi lumen]
Reactome.org reaction link: R-HSA-4085033
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
alpha-D-galactosyl group
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
alpha-N-acetylneuraminyl-(2->6)-D-galactosyl group
Reactome.org link: R-HSA-4085033