Reaction: PDE6 hydrolyses cGMP to GMP
- in pathway: Ca2+ pathway
WNT signaling through WNT5A and FZD2 leads to a decrease in intracellular cGMP levels in a manner that is dependent on G alpha t2 and PDE6 (Ahumada et al, 2002; Ma and Wang, 2006; Ma and Wang, 2007, Bazhin et al, 2010). In response to decreasing cGMP levels, the activity of cGMP-dependent protein kinase G (PKG) also decreases, and this reduction in PKG activity is required both for intracellular calcium release and for activation of NFAT-dependent transcription in response to WNT5A (Ma and Wang, 2006).
Reaction - small molecule participants:
GMP [cytosol]
cGMP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-4086392
======
Reaction input - small molecules:
3',5'-cyclic GMP
water
Reaction output - small molecules:
guanosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-4086392