Reaction: PLK1 phosphorylates FOXM1
- in pathway: Polo-like kinase mediated events
PLK1 phosphorylates FOXM1 on serine residues S730 and S739 (S715 and S724 in FOXM1B isoform) in the C-terminal transactivation domain (TAD). PLK1-mediated phosphorylation of FOXM1 upregulates FOXM1 transcriptional activity and is crucial for FOXM1 function at G2/M transition (Fu et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-4088134
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-4088134