Reaction: PTGFR binds PGF2a
- in pathway: Prostanoid ligand receptors
Prostaglandin F receptor (FP) is a GPCR for Prostaglandin F2alpha and is encoded by the PTGFR gene (Abramovitz M et al, 1994). Main effects of prostaglandin binding to the receptor are uterine contraction and bronchoconstriction. These effects are mediated by coupling with the G protein alpha q/11 subunit which activates a phosphatidylinositol-calcium second messenger system (Carrasco MP et al, 1997).
Reaction - small molecule participants:
PGF2a [extracellular region]
Reactome.org reaction link: R-HSA-416929
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Reaction input - small molecules:
prostaglandin F2alpha
Reaction output - small molecules:
Reactome.org link: R-HSA-416929